Article
Hyperfunction variant rs708035 of interleukin 1 receptor-associated kinases 2 gene involved in the predisposition of leprosy infection.
The journal of gene medicine - 1 Apr 2023
Saleem Saima, Zia Mutaher, Siddiqui Farhatulain, Ghouri Maham, Kulsoom Ume, Kawal Sidra, Fatima Sehrish, Zehra Sitwat
Abstract excerpt
BACKGROUND: Mycobacterium leprae (slow-growing bacteria) is the etiological agent for leprosy infection, which is a chronic granulomatous disease. Symptoms initiate with the loss of sensation in the affected areas, which can lead to severe injuries, cuts and burns. IRAK2 (interleukin-1 receptor-associated kinases 2) is reported to function in the regulation of the NFκB pathway. The frequency of the IRAK2...
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