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Article

Evaluation and Determination of a Suitable Passage Number of Codon Pair Deoptimized PRRSV-1 Vaccine Candidate in Pigs.

Viruses - 27 Apr 2023

Lee Min-A, You Su-Hwa, Jayaramaiah Usharani, Shin Eun-Gyeong, Song Seung-Min, Ju Lanjeong, Kang Seok-Jin, Cho Sun-Hee, Hyun Bang-Hun, Lee Hyang-Sim

Abstract excerpt

Porcine reproductive and respiratory syndrome virus (PRRSV) is major economic problem given its effects on swine health and productivity. Therefore, we evaluated the genetic stability of a codon pair de-optimized (CPD) PRRSV, E38-ORF7 CPD, as well as the master seed passage threshold that elicited an effective immune response in pigs against heterologous virus challenge. The genetic stability and immune response...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 37243157
DOI: 10.3390/v15051071
PMCID: PMC10220689

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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