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Colorectal cancer. Genetic variants in BMP signaling pathway and ancestry in the Mexican population.

Gaceta medica de Mexico - 1 Jan 2022

Haro-Santa-Cruz Jorge, Colistro Valentina, Cárdenas-Cadena Sergio, Luna-Pérez Pedro, García-González Irma S, Sans Mónica, Carracedo Ángel, Cruz Raquel, Castelán-Maldonado Edmundo, Murillo-Martínez Carlos, Jaramillo-Rodríguez Yolanda, Borrego-Soto Gissela, Ruiz-Flores Pablo, Ortiz-López Rocío, Rojas-Martínez Augusto

Abstract excerpt

INTRODUCTION: Genetic variants related to bone morphogenetic proteins (BMP2, BMP4, GREM1, SMAD7) signaling pathway have been associated with colorectal cancer, mainly in Caucasian populations. OBJECTIVE: To describe the association of variants in members of the BMP signaling pathway in a Mexican population, characterized by its indigenous American and Caucasian ancestry. METHODS: Genotyping of 1,000 colorectal...

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PMID: 36657129
DOI: 10.24875/GMM.M22000720

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