Article
Single nucleotide polymorphisms in the Wnt and BMP pathways and colorectal cancer risk in a Spanish cohort.
PloS one - 9 Sept 2010
Fernández-Rozadilla Ceres, de Castro Luisa, Clofent Juan, Brea-Fernández Alejandro, Bessa Xavier, Abulí Anna, Andreu Montserrat, Jover Rodrigo, Xicola Rosa, Llor Xavier, Castells Antoni, Castellví-Bel Sergi, Carracedo Angel, Ruiz-Ponte Clara
Abstract excerpt
BACKGROUND: Colorectal cancer (CRC) is considered a complex disease, and thus the majority of the genetic susceptibility is thought to lie in the form of low-penetrance variants following a polygenic model of inheritance. Candidate-gene studies have so far been one of the basic approaches taken t...
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