Article
Evaluation of germline BMP4 mutation as a cause of colorectal cancer.
Human mutation - 1 Jan 2011
Lubbe Steven J, Pittman Alan M, Matijssen Cornelis, Twiss Philip, Olver Bianca, Lloyd Amy, Qureshi Mobshra, Brown Nathan, Nye Emma, Stamp Gordon, Blagg Julian, Houlston Richard S
Abstract excerpt
Transforming growth factor-β (TGF-β) signalling plays a key role in colorectal cancer (CRC). Bone morphogenetic protein-4 (BMP4) is a member of the TGF-β family of signal transduction molecules. To examine if germline mutation in BMP4 causes CRC we analysed 504 genetically enriched CRC cases (by virtue of early-onset disease, family history of CRC) for mutations in the coding sequence of BMP4. We identified three...
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