Article
Expression of RANKL in breast cancer tissue in patients with fibrous dysplasia/McCune-Albright syndrome.
Bone - 1 Apr 2023
Meier M E, Hagelstein-Rotman M, Majoor B C J, Geels R E S, Appelman-Dijkstra N M, Bravenboer N
Abstract excerpt
BACKGROUND: In fibrous dysplasia/McCune-Albright syndrome (FD/MAS), mosaic mutations in the GNAS gene lead to locally abnormal bone turnover. Additionally, patients with FD/MAS, particularly with thoracic lesions, have an increased risk for breast cancer. Development and progression of breast cancer has been associated with expression of Receptor Activator of NF-κB ligand (RANKL) in mammary tissue, and due to the...
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