G(s)alpha mutations in fibrous dysplasia and McCune-Albright syndrome.

Abstract excerpt

Fibrous dysplasia (FD) is a focal bone lesion composed of immature mesenchymal osteoblastic precursor cells. Some FD patients also have hyperpigmented skin lesions (café-au-lait spots), gonadotropin-independent sexual precocity, and/or other endocrine and nonendocrine manifestations (McCune-Albright syndrome [MAS]). MAS results from somatic mutations occurring during early development, resulting in a widespread...

Topics

• Cyclic AMP
• Endocrine Gland Neoplasms
• Fibrous Dysplasia of Bone
• Fibrous Dysplasia, Polyostotic
• GTP-Binding Protein alpha Subunits, Gs
• Humans
• Mutation