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Article

Activating mutations of Gs protein in monostotic fibrous lesions of bone.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Mar 1996

Alman B A, Greel D A, Wolfe H J

Abstract excerpt

Activating mutations of the alpha chain of the heterotrimeric signal transducer Gs disrupt the inherent guanosine triphosphatase activity of the alpha chain, stimulate adenylyl cyclase, and can result in independent cell proliferation. Such mutations are identified in a number of endocrine disorders, including McCune-Albright syndrome, which is a triad of endocrinopathy, café au lait spots, and polyostotic...

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Identifiers

PMID: 8648511
DOI: 10.1002/jor.1100140221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Activating mutations of Gs protein in monostotic fibrous lesions of bone.PMID 8648511Read ↗

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Fibrous dysplasia/McCune-Albright syndrome: state-of-the-art advances, pathogenesis, and basic/translational researchSemantic proximity Read ↗

Fibrous Dysplasia/McCune-Albright Syndrome: A Rare, Mosaic Disease of Gα s ActivationSemantic proximity Read ↗

G(s)alpha mutations in fibrous dysplasia and McCune-Albright syndrome.Semantic proximity Read ↗

Mutations of the GNAS1 gene, stromal cell dysfunction, and osteomalacic changes in non-McCune-Albright fibrous dysplasia of bone.Semantic proximity Read ↗

Identification of a mutation in the gene encoding the alpha subunit of the stimulatory G protein of adenylyl cyclase in McCune-Albright syndrome.Semantic proximity Read ↗

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Osteoblastic cells derived from isolated lesions of fibrous dysplasia contain activating somatic mutations of the Gs alpha gene.Semantic proximity Read ↗

Current concepts of craniofacial fibrous dysplasia: pathophysiology and treatmentSemantic proximity Read ↗

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