Activating mutations of Gs protein in monostotic fibrous lesions of bone.

doi:10.1002/jor.1100140221

Back to search

Article

Activating mutations of Gs protein in monostotic fibrous lesions of bone.

Journal of orthopaedic research : official publication of the Orthopaedic Research Society - 1 Mar 1996

Alman B A, Greel D A, Wolfe H J

Abstract excerpt

Activating mutations of the alpha chain of the heterotrimeric signal transducer Gs disrupt the inherent guanosine triphosphatase activity of the alpha chain, stimulate adenylyl cyclase, and can result in independent cell proliferation. Such mutations are identified in a number of endocrine disord...

Topics

Adolescent
Adult
Blotting, Southern
Bone Neoplasms
Bone and Bones
Child
Exons
Female
Desmoid Tumors
Fibrous Dysplasia of Bone
Fibrous Dysplasia, Monostotic
GTP-Binding Proteins
Humans
Male
Mutation

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.