Article
The PIK3CA-E545K-SIRT4 signaling axis reduces radiosensitivity by promoting glutamine metabolism in cervical cancer.
Cancer letters - 1 Mar 2023
Jiang Wei, Ouyang Xueyan, Ji Zhaodong, Shi Wanling, Wu Yutuan, Yao Qianlan, Wang Yi, Yang Wentao, Xiang Libing, Yang Huijuan
Abstract excerpt
The mutation of glutamic acid 545 to lysine (E545K) in PIK3CA, as the most common missense mutation of this gene in various cancer types, is frequently observed in cervical cancer and has been shown to reduce cervical cancer radiosensitivity. However, the underlying mechanisms remain unclear. Here, we implicate the alterations of glutamine metabolism in PIK3CA-E545K-mediated radioresistance of cervical cancer....
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