Article

Metabolic remodeling by TIGAR overexpression is a therapeutic target in esophageal squamous-cell carcinoma

2019-10-01

Abstract excerpt

<h4>Summary</h4> Whole-genome sequencing has identified many amplified genes in esophageal squamous-cell carcinoma (ESCC); however, their roles and the clinical relevance have yet elucidated. Here we show TP53-induced glycolysis and apoptosis regulator (TIGAR) is a major player in ESCC progression and chemoresistance. TIGAR reprograms glucose metabolism from glycolysis to the glutamine pathway through AMP-activat...

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Literature Corpus work: 66a2b0c4-f3fc-550c-b5a6-b5fa7f610e4e
DOI: 10.1101/789271

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