Article

SIRT4 functions as a tumor suppressor in prostate cancer by inducing apoptosis and inhibiting glutamine metabolism

2022-05-27

Abstract excerpt

SIRT4, localized in the mitochondria, is an nicotinamide adenine dinucleotide (NAD+) -dependent adenosine diphosphate (ADP) -ribosyltransferase and is one of the least characterized members of the sirtuin family. Although it is well known that it shows deacetylase activity for energy metabolism, little is understood about its function in tumorigenesis. Recent research suggests that SIRT4 may work as both a tumor s...

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Literature Corpus work: 7af2997b-0fee-5e62-b35e-f611b664c762
DOI: 10.21203/rs.3.rs-1417679/v2

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