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Article

Decreased sirtuin 4 expression is associated with poor prognosis in patients with invasive breast cancer

16 Aug 2016

Abstract excerpt

Aberrant metabolism is a hallmark of human cancer. Glutamine metabolism has been identified as a central metabolic pathway in cancer and thus, targeting glutamine metabolism may exhibit therapeutic potential. Sirtuin 4 (SIRT4) is an important molecule that mediates the blockade of glutamine catabolism by inhibiting glutamate dehydrogenase. In the present study, SIRT4 protein expression levels were analyzed in 409...

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PMID: 27698834
DOI: 10.3892/ol.2016.5021

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