Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase.

PloS one - 5 May 2010

Li SiDe, Banck Michaela, Mujtaba Shiraz, Zhou Ming-Ming, Sugrue Mary M, Walsh Martin J

Abstract excerpt

A hallmark of p53 function is to regulate a transcriptional program in response to extracellular and intracellular stress that directs cell cycle arrest, apoptosis, and cellular senescence. Independent of the role of p53 in the nucleus, some of the anti-proliferative functions of p53 reside within the mitochondria [1]. p53 can arrest cell growth in response to mitochondrial p53 in an EJ bladder carcinoma cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Acetylation
Share to Cellular Senescence
Share to HSP70 Heat-Shock Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Proto-Oncogene Proteins c-bcl-2

Share to Sirtuin 3

Share to Subcellular Fractions

Share to Urinary Bladder Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 20463968
DOI: 10.1371/journal.pone.0010486
PMCID: PMC2864751

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

p53-induced growth arrest is regulated by the mitochondrial SirT3 deacetylase.PMID 20463968Read ↗

SirT3 Regulates the Mitochondrial Unfolded Protein ResponseSemantic proximity Read ↗

Sirtuin 3: A Janus face in cancer (Review)Semantic proximity Read ↗

SIRT3: Oncogene and Tumor Suppressor in CancerSemantic proximity Read ↗

Sirt3, Mitochondrial ROS, Ageing, and CarcinogenesisSemantic proximity Read ↗

SIRT3 Is a Mitochondria-Localized Tumor Suppressor Required for Maintenance of Mitochondrial Integrity and Metabolism during StressSemantic proximity Read ↗

Are the estrogen receptor and SIRT3 axes of the mitochondrial UPR key regulators of breast cancer subtype determination according to age?Semantic proximity Read ↗

SIRT3 Functions in the Nucleus in the Control of Stress-Related Gene ExpressionSemantic proximity Read ↗

Role of p53 in the anti-proliferative effects of Sirt1 inhibition in prostate cancer cellsSemantic proximity Read ↗

Increased expression of SIRT2 is a novel marker of cellular senescence and is dependent on wild type p53 statusSemantic proximity Read ↗

Wild-type p53 triggers a rapid senescence program in human tumor cells lacking functional p53Semantic proximity Read ↗

SIRT3 Is a Stress-Responsive Deacetylase in Cardiomyocytes That Protects Cells from Stress-Mediated Cell Death by Deacetylation of Ku70Semantic proximity Read ↗

Cancer-Specific Functions of SIRT1 Enable Human Epithelial Cancer Cell Growth and SurvivalSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.