Article
Loss of p62 Binding Allows TIF-IA Accumulation in Senescence, Which Promotes Phenotypic Changes to Nucleoli and the Senescence Associated Secretory Phenotype.
Aging cell - 1 Jan 2026
Thoms Hazel C, Brant Tyler S, Duckett Katie, Yang Yizheng, Dong Jinxi, Wang Hongfei, Derby Freya, Akeke Oluwatumilara F, Al-Alayeen Faizah, Newell Amy, Manasterski Piotr, Gopalakrishnan Aishwarya, Mann Derek, Millar Fraser R, Von Kriegsheim Alex, Acosta Juan Carlos, Oakley Fiona, Stark Lesley A
Abstract excerpt
A key characteristic of senescent and ageing cells is a reduction in number and increase in size of nucleoli. Although a number of pathways have been suggested, the mechanisms underlying this altered nucleolar phenotype, and the downstream consequences, remain poorly understood. The PolI complex component, TIF-IA, has previously been implicated in regulating this characteristic nucleolar phenotype in response to...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.