Article

Feeder-free generation of functional dendritic cells from human pluripotent stem cells

2025-11-14

Abstract excerpt

The scarcity of primary conventional dendritic cells (cDCs) and the limited effectiveness of monocyte-derived dendritic cells (moDCs) have long hindered progress in human dendritic cell research and immunotherapy. We developed a feeder-free differentiation platform that generates CD1c + CD141 + hPSC-cDCs phenotypically aligned with CD141 + tissue-resident cDC2 subsets found in human tissues. We further optimize...

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Literature Corpus work: 1c4ab7ad-ac4b-5338-93e7-cbe12c82245b
DOI: 10.1101/2025.11.13.687739

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