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Urokinase plasminogen activator surface receptor restricts HIV-1 replication by blocking virion release from the cell membrane

13 Jan 2023

Abstract excerpt

The urokinase-type plasminogen activator (uPA) system consists of the proteinase uPA, its receptor (PLAUR/uPAR). Under physiological conditions, uPA and PLAUR are predominantly expressed by blood cells, including neutrophils, monocytes, and macrophages, and play important roles in cell activation, adhesion, migration, and extravasation. Here, we report that PLAUR, which is highly expressed in macrophages and...

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PMID: 36638209
DOI: 10.1073/pnas.2212991120

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