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COVID-19 and pneumonia: a role for the uPA/uPAR system

17 Jun 2020

Abstract excerpt

Here, we highlight recent findings on the urokinase plasminogen activator (uPA)/uPA receptor (uPAR) system that suggest its potential role as a main orchestrator of fatal progression to pulmonary, kidney, and heart failure in patients with coronavirus. Patients with prolonged background inflammation can present aberrant inflammatory reactions, well recognized as the main factors that can result in death and...

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PMID: 32562843
DOI: 10.1016/j.drudis.2020.06.013

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