Article

Crystal Structure and Cellular Functions of uPAR Dimer

2021-08-17

Abstract excerpt

<title>Abstract</title> <p>Receptor dimerization of urokinase-type plasminogen activator receptor (uPAR) was previously identified at protein level and on the cell surface. Recently, a dimeric form of mouse uPAR isoform 2 was proposed, which induced kidney disease. Here, we report the crystal structure of human uPAR dimer at 2.96 Å. The structure reveals enormous conformational changes of the dimer compared to th...

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Literature Corpus work: a9dd445a-7536-5911-8977-17d5468c55cb
DOI: 10.21203/rs.3.rs-802899/v1

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