Article

HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophages

2023-03-21

Abstract excerpt

<h4>ABSTRACT</h4> HIV-1 Vpr promotes efficient spread of HIV-1 from macrophages to T cells by transcriptionally downmodulating restriction factors that target HIV-1 Envelope protein (Env). Here we find that Vpr induces broad transcriptomic changes by targeting PU.1, a transcription factor necessary for expression of host innate immune response genes, including those that target Env. Consistent with this, we find...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c906630f-5634-5617-98b2-0b088f370129
DOI: 10.1101/2023.03.21.533528

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

HIV-1 Vpr combats the PU.1-driven antiviral response in primary human macrophagesDOI 10.1101/2023.03.21.533528Read

Illuminating the Role of Vpr in HIV Infection of Myeloid CellsSemantic proximity Read

The Human Immunodeficiency Virus Type 2 Vpx Protein Usurps the CUL4A-DDB1 DCAF1 Ubiquitin Ligase To Overcome a Postentry Block in Macrophage InfectionSemantic proximity Read

HIV-1 Vpr-induced DNA damage activates NF-κB through ATM-NEMO independent of cell cycle arrestSemantic proximity Read

Macrophages and HIV-1Semantic proximity Read

Mannose receptor is an HIV restriction factor counteracted by Vpr in macrophagesSemantic proximity Read

HIV-1 Vpr-induced DNA damage activates NF-κB through ATM-NEMO independent of cell cycle arrestSemantic proximity Read

Distinct Effects in Primary Macrophages and Lymphocytes of the Human Immunodeficiency Virus Type 1 Accessory Genes vpr, vpu, and nef: Mutational Analysis of a Primary HIV-1 IsolateSemantic proximity Read

HIV-1 Accessory Protein Vpr: Relevance in the pathogenesis of HIV and potential for therapeutic interventionSemantic proximity Read

Multi-Omics Single-Cell Analysis Reveals Key Regulators of HIV-1 Persistence and Aberrant Host Immune Responses in Early InfectionSemantic proximity Read

The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infectionSemantic proximity Read

A New Type of Nonsuppressible Viremia Produced by HIV-Infected MacrophageSemantic proximity Read

The functions of the HIV1 protein Vpr and its action through the DCAF1·DDB1·Cullin4 ubiquitin ligaseSemantic proximity Read