Article
Multi-omic association study identifies DNA methylation-mediated genotype and smoking exposure effects on lung function in children living in urban settings.
PLoS genetics - 1 Jan 2023
Dapas Matthew, Thompson Emma E, Wentworth-Sheilds William, Clay Selene, Visness Cynthia M, Calatroni Agustin, Sordillo Joanne E, Gold Diane R, Wood Robert A, Makhija Melanie, Khurana Hershey Gurjit K, Sherenian Michael G, Gruchalla Rebecca S, Gill Michelle A, Liu Andrew H, Kim Haejin, Kattan Meyer, Bacharier Leonard B, Rastogi Deepa, Altman Matthew C, Busse William W, Becker Patrice M, Nicolae Dan, O'Connor George T, Gern James E, Jackson Daniel J, Ober Carole
Abstract excerpt
Impaired lung function in early life is associated with the subsequent development of chronic respiratory disease. Most genetic associations with lung function have been identified in adults of European descent and therefore may not represent those most relevant to pediatric populations and populations of different ancestries. In this study, we performed genome-wide association analyses of lung function in a...
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