Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Mitochondria-Related Pathogenic Genes in Paediatric Asthma: A Multi-Omics Mendelian Randomization Study.

Journal of cellular and molecular medicine - 1 Apr 2026

Zhang Biyu, Li Yaqin, Ding Bo, Li Xiaoyan, Lu Yanming

Abstract excerpt

Mitochondrial dysfunction is implicated in asthma pathogenesis, but causal roles of mitochondrial-related genes in paediatric asthma remain unclear. We performed a multi-omics Mendelian randomization study integrating GWAS data from paediatric asthma cohorts with blood-based methylation quantitative trait loci (mQTLs), expression QTLs (eQTLs) and protein QTLs (pQTLs) datasets. Causal inference was assessed using...

Topics

Join the communities discussing this publication.

Asthma
DNA Methylation
Mendelian Randomization Analysis
Mitochondria
Multiomics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Interaction Maps

Quantitative Trait Loci

Source

Open in PubMed Open full text

Identifiers

PMID: 41896191
DOI: 10.1111/jcmm.71102
PMCID: PMC13140575

Genes

ALAS1
TXNRD1
STX17
ATP5MC1
GLDC
MFN2
PHB2
SDHB
UNG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mitochondria-Related Pathogenic Genes in Paediatric Asthma: A Multi-Omics Mendelian Randomization Study.PMID 41896191Read ↗

A multi-omics and mediation-based genetic screening approach identifies STX4 as a key link between epigenetic regulation, immune cells, and childhood asthmaSemantic proximity Read ↗

Integrating Multi-Omics Data to Uncover Causal Links Between Mitochondria-Related Genes and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Study.Semantic proximity Read ↗

A multi-omics Mendelian randomization identiﬁes putatively causal genes and DNA methylation sites for asthmaSemantic proximity Read ↗

Unspecified asthma, childhood-onset, and adult-onset asthma have different causal genes: a Mendelian randomization analysis.Semantic proximity Read ↗

From early-onset asthma to chronic obstructive pulmonary disease: potential mediating proteins and therapeutic targets.Semantic proximity Read ↗

Multi-ancestry meta-analysis of asthma identifies novel associations and highlights the value of increased power and diversitySemantic proximity Read ↗

Epigenome-wide association study of asthma and wheeze in childhood and adolescenceSemantic proximity Read ↗

Identification and genetic validation of potential therapeutic targets for pulmonary hypertension through multi-omics causal inference.Semantic proximity Read ↗

Novel Genetic Risk factors for Asthma in African American Children: Precision Medicine and The SAGE II StudySemantic proximity Read ↗

The Role of Programmed Cell Death-Related Genes in Asthma, Chronic Obstructive Pulmonary Disease, and Lung Function: A Multi-Omics Mendelian Randomization Study.Semantic proximity Read ↗

Epigenome-wide association study of asthma and wheeze in childhood and adolescence.Semantic proximity Read ↗

Novel genetic risk factors for asthma in African American children: Precision Medicine and the SAGE II Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.