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Article

DNA Methylation-Mediated Downregulation of SDK1 Promotes COPD Progression: A Multi-Omics Mendelian Randomization Study.

International journal of chronic obstructive pulmonary disease - 1 Jan 2025

Xue Zhichun, Xue Qing, Deng Xinyu, Li Shuqi, Liang Peng, Chen Huiling, Xue Hong, Fang Guiju

Abstract excerpt

Purpose: To systematically explore the potential causal relationships among gene expression, DNA methylation, and chronic obstructive pulmonary disease (COPD) susceptibility using a multi-omics Mendelian randomization (MR) framework, and to further investigate key regulatory genes and methylation sites potentially involved in COPD pathogenesis. Patients and Methods: We integrated genome-wide association study...

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Share to Disease Progression
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Pulmonary Disease, Chronic Obstructive

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Source

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Identifiers

PMID: 41126804
DOI: 10.2147/COPD.S534335
PMCID: PMC12537812

Genes

SDK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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