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Article

Comparison of transcriptome profiles between medulloblastoma primary and recurrent tumors uncovers novel variance effects in relapses.

Acta neuropathologica communications - 12 Jan 2023

Okonechnikov Konstantin, Federico Aniello, Schrimpf Daniel, Sievers Philipp, Sahm Felix, Koster Jan, Jones David T W, von Deimling Andreas, Pfister Stefan M, Kool Marcel, Korshunov Andrey

Abstract excerpt

Nowadays medulloblastoma (MB) tumors can be treated with risk-stratified approaches with up to 80% success rate. However, disease relapses occur in approximately 30% of patients and successful salvage treatment strategies at relapse remain scarce. Acquired copy number changes or TP53 mutations are known to occur frequently in relapses, while methylation profiles usually remain highly similar to those of the...

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Identifiers

PMID: 36635768
DOI: 10.1186/s40478-023-01504-1
PMCID: PMC9837941

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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