Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Multidimensional analysis of matched primary and recurrent glioblastoma identifies contributors to tumor recurrence influencing time to relapse

23 Sept 2024

Abstract excerpt

Glioblastoma (GBM) is a lethal brain tumor without effective treatment options. This study aimed to characterize longitudinal tumor changes in order to find potentially actionable targets to prevent GBM relapse. We extracted RNA and proteins from fresh frozen tumor samples from patient-matched IDHwt WHO grade 4 primary (pGBM) and recurrent (rGBM) tumors for transcriptomics and proteomics analysis. A tissue...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Glioma Diagnosis and Treatment
Share to MicroRNA in disease regulation
Share to Neuroinflammation and Neurodegeneration Mechanisms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 39423857
DOI: 10.1093/jnen/nlae108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Multidimensional analysis of matched primary and recurrent glioblastoma identifies contributors to tumor recurrence influencing time to relapsePMID 39423857Read ↗

Multidimensional analysis of matched primary and recurrent glioblastoma identifies Fcγ receptors upregulation on microglia as a contributor of tumor recurrenceSemantic proximity Read ↗

Decoding key cell sub-populations and molecular alterations in glioblastoma at recurrence by single-cell analysisSemantic proximity Read ↗

A longer time to relapse is associated with a larger increase in differences between paired primary and recurrent IDH wild-type glioblastomas at both the transcriptomic and genomic levels.Semantic proximity Read ↗

Expression Profiling of Primary and Recurrent Glioblastomas Reveals a Reduced Level of Pentraxin 3 in Recurrent GlioblastomasSemantic proximity Read ↗

Fc gamma receptor IIb in tumor-associated macrophages and dendritic cells drives poor prognosis of recurrent glioblastoma through immune-associated signaling pathwaysSemantic proximity Read ↗

Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastomaSemantic proximity Read ↗

Identification of the immune gene expression signature associated with recurrence of high-grade gliomas.Semantic proximity Read ↗

Longitudinal multi-omics characterization of the malignant evolution in multirelapsing glioblastomaSemantic proximity Read ↗

Tumor evolution of glioma intrinsic gene expression subtype associates with immunological changes in the microenvironmentSemantic proximity Read ↗

Construction and Validation of a Recurrence Prediction Model of Glioblastoma and Exploration of Its Biological FunctionsSemantic proximity Read ↗

Transcriptome analysis reveals tumor microenvironment changes in glioblastomaSemantic proximity Read ↗

Atypical behavior of recurrent glioblastoma tumor cells with a highly adherent radial glial phenotype.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.