Article

Adaptive Convergence of Methylomes Reveals Epigenetic Drivers and Boosters of Repeated Relapses in Patient-matched Childhood Ependymomas and Identifies Targets for Anti-Recurrence Therapies

2021-10-05

Abstract excerpt

<title>Abstract</title> <p>Ependymoma (EPN) is the third most common brain tumor in children and frequently recurs. Here, we report an integrated longitudinal analysis of epigenetic, genetic and tumorigenic changes in 30 patient-matched repeated relapses obtained from 10 pediatric patients to understand the mechanism of recurrences. Genome-wide DNA methylation analysis revealed stable molecular subtypes and conve...

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Literature Corpus work: d2c52d3a-e6d1-509a-aa48-e95ecabbccf7
DOI: 10.21203/rs.3.rs-908607/v1

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Adaptive Convergence of Methylomes Reveals Epigenetic Drivers and Boosters of Repeated Relapses in Patient-matched Childhood Ependymomas and Identifies Targets for Anti-Recurrence TherapiesDOI 10.21203/rs.3.rs-908607/v1Read

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