Article
Novel molecular subgroups for clinical classification and outcome prediction in childhood medulloblastoma: a cohort study.
The Lancet. Oncology - 1 Jul 2017
Schwalbe Edward C, Lindsey Janet C, Nakjang Sirintra, Crosier Stephen, Smith Amanda J, Hicks Debbie, Rafiee Gholamreza, Hill Rebecca M, Iliasova Alice, Stone Thomas, Pizer Barry, Michalski Antony, Joshi Abhijit, Wharton Stephen B, Jacques Thomas S, Bailey Simon, Williamson Daniel, Clifford Steven C
Abstract excerpt
BACKGROUND: International consensus recognises four medulloblastoma molecular subgroups: WNT (MBWNT), SHH (MBSHH), group 3 (MBGrp3), and group 4 (MBGrp4), each defined by their characteristic genome-wide transcriptomic and DNA methylomic profiles. These subgroups have distinct clinicopathological and molecular features, and underpin current disease subclassification and initial subgroup-directed therapies that...
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