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Article

Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas

5 Nov 2022

Abstract excerpt

Recurrence is frequent in pediatric ependymoma (EPN). Our longitudinal integrated analysis of 30 patient-matched repeated relapses (3.67 ± 1.76 times) over 13 years (5.8 ± 3.8) reveals stable molecular subtypes (RELA and PFA) and convergent DNA methylation reprogramming during serial relapses accompanied by increased orthotopic patient derived xenograft (PDX) (13/27) formation in the late recurrences. A set of...

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PMID: 36335125
DOI: 10.1038/s41467-022-34514-z

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