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Article

Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases.

Structure (London, England : 1993) - 4 Feb 2020

Dornan Gillian L, Stariha Jordan T B, Rathinaswamy Manoj K, Powell Cameron J, Boulanger Martin J, Burke John E

Abstract excerpt

The class I phosphoinositide 3-kinases (PI3Ks) are key signaling enzymes composed of a heterodimer of a p110 catalytic subunit and a p85 regulatory subunit, with PI3K mutations being causative of multiple human diseases including cancer, primary immunodeficiencies, and developmental disorders. Mutations in the p85α regulatory subunit encoded by PIK3R1 can both activate PI3K through oncogenic truncations in the...

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PMID: 31831213
DOI: 10.1016/j.str.2019.11.013

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Defining How Oncogenic and Developmental Mutations of PIK3R1 Alter the Regulation of Class IA Phosphoinositide 3-Kinases.PMID 31831213Read ↗

Defining how oncogenic and developmental mutations of <i>PIK3R1</i> alter the regulation of class IA phosphoinositide 3-kinasesSemantic proximity Read ↗

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