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Article

PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective.

Cancer research - 15 Jan 2021

Zhang Mingzhen, Jang Hyunbum, Nussinov Ruth

Abstract excerpt

Ras activates its effectors at the membrane. Active PI3Kα and its associated kinases/phosphatases assemble at membrane regions enriched in signaling lipids. In contrast, the Raf kinase domain extends into the cytoplasm and its assembly is away from the crowded membrane surface. Our structural membrane-centric outlook underscores the spatiotemporal principles of membrane and signaling lipids, which helps clarify...

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Identifiers

PMID: 33046444
DOI: 10.1158/0008-5472.CAN-20-0911
PMCID: PMC7855922

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