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Mutagenesis induced by protonation of single-stranded DNA is linked to glycolytic sugar metabolism.

Mutation research - 1 Jan 2000

Gelova Suzana P, Chan Kin

Abstract excerpt

Mutagenesis can be thought of as random, in the sense that the occurrence of each mutational event cannot be predicted with precision in space or time. However, when sufficiently large numbers of mutations are analyzed, recurrent patterns of base changes called mutational signatures can be identified. To date, some 60 single base substitution or SBS signatures have been derived from analysis of cancer genomics...

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PMID: 36634476
DOI: 10.1016/j.mrfmmm.2023.111814

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