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Present and Future Perspective on PLK1 Inhibition in Cancer Treatment

2 Jun 2022

Abstract excerpt

Polo-like kinase 1 (PLK1) is the principle member of the well conserved serine/threonine kinase family. PLK1 has a key role in the progression of mitosis and recent evidence suggest its important involvement in regulating the G2/M checkpoint, in DNA damage and replication stress response, and in cell death pathways. PLK1 expression is tightly spatially and temporally regulated to ensure its nuclear activation at...

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PMID: 35719948
DOI: 10.3389/fonc.2022.903016

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