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Targeting Polo-Like Kinases: A Promising Therapeutic Approach for Cancer Treatment

1 Jun 2015

Abstract excerpt

Polo-like kinases (Plks) are a family of serine-threonine kinases that regulate multiple intracellular processes including DNA replication, mitosis, and stress response. Plk1, the most well understood family member, regulates numerous stages of mitosis and is overexpressed in many cancers. Plk inhibitors are currently under clinical investigation, including phase III trials of volasertib, a Plk inhibitor, in...

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PMID: 26055176
DOI: 10.1016/j.tranon.2015.03.010

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