Article
Structural basis for transcription factor ZBTB7A recognition of DNA and effects of ZBTB7A somatic mutations that occur in human acute myeloid leukemia.
The Journal of biological chemistry - 1 Feb 2023
Ren Ren, Horton John R, Chen Qin, Yang Jie, Liu Bin, Huang Yun, Blumenthal Robert M, Zhang Xing, Cheng Xiaodong
Abstract excerpt
ZBTB7A belongs to a small family of transcription factors having three members in humans (7A, 7B, and 7C). They share a BTB/POZ protein interaction domain at the amino end and a zinc-finger DNA-binding domain at the carboxyl end. They control the transcription of a wide range of genes, having varied functions in hematopoiesis, oncogenesis, and metabolism (in particular glycolysis). ZBTB7A-binding profiles at gene...
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