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Oncogenic mutations in the FBXW7 gene of adult T-cell leukemia patients

31 May 2016

Abstract excerpt

Human T-cell leukemia virus type 1 (HTLV-I) is associated with adult T-cell leukemia (ATL), an aggressive lymphoproliferative disease with a dismal prognosis. We have previously described the presence of Notch1 activating mutations and constitutive Notch1 signaling in patients with acute ATL. In this study, we report a high frequency of F-box and WD repeat domain containing 7 (FBXW7)/hCDC4 mutations within the...

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PMID: 27247421
DOI: 10.1073/pnas.1601537113

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