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Article

Somatic human ZBTB7A zinc finger mutations promote cancer progression.

Oncogene - 9 Jun 2016

Liu X-S, Liu Z, Gerarduzzi C, Choi D E, Ganapathy S, Pandolfi P P, Yuan Z-M

Abstract excerpt

We recently reported that ZBTB7A is a bona fide transcription repressor of key glycolytic genes and its downregulation in human cancer contributes to tumor metabolism. As reduced expression of ZBTB7A is found only in a subset of human cancers, we explored alternative mechanisms of its inactivation by mining human cancer genome databases. We discovered recurrent somatic mutations of ZBTB7A in multiple types of...

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Identifiers

PMID: 26455326
DOI: 10.1038/onc.2015.371
PMCID: PMC5817916

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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