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Mutational profile of ZBTB16‐RARA‐positive acute myeloid leukemia

27 May 2021

Abstract excerpt

BACKGROUND: The ZBTB16-RARA fusion gene, resulting from the reciprocal translocation between ZBTB16 on chromosome 11 and RARA genes on chromosome 17 [t(11;17)(q23;q21)], is rarely observed in acute myeloid leukemia (AML), and accounts for about 1% of retinoic acid receptor-α (RARA) rearrangements. AML with this rare translocation shows unusual bone marrow (BM) morphology, with intermediate aspects between acute...

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PMID: 34042280
DOI: 10.1002/cam4.3904

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