ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.

doi:10.1038/ncomms11733

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Article

ZBTB7A mutations in acute myeloid leukaemia with t(8;21) translocation.

Nature communications - 2 Jun 2016

Hartmann Luise, Dutta Sayantanee, Opatz Sabrina, Vosberg Sebastian, Reiter Katrin, Leubolt Georg, Metzeler Klaus H, Herold Tobias, Bamopoulos Stefanos A, Bräundl Kathrin, Zellmeier Evelyn, Ksienzyk Bianka, Konstandin Nikola P, Schneider Stephanie, Hopfner Karl-Peter, Graf Alexander, Krebs Stefan, Blum Helmut, Middeke Jan Moritz, Stölzel Friedrich, Thiede Christian, Wolf Stephan, Bohlander Stefan K, Preiss Caroline, Chen-Wichmann Linping, Wichmann Christian, Sauerland Maria Cristina, Büchner Thomas, Berdel Wolfgang E, Wörmann Bernhard J, Braess Jan, Hiddemann Wolfgang, Spiekermann Karsten, Greif Philipp A

Abstract excerpt

The t(8;21) translocation is one of the most frequent cytogenetic abnormalities in acute myeloid leukaemia (AML) and results in the RUNX1/RUNX1T1 rearrangement. Despite the causative role of the RUNX1/RUNX1T1 fusion gene in leukaemia initiation, additional genetic lesions are required for disease development. Here we identify recurring ZBTB7A mutations in 23% (13/56) of AML t(8;21) patients, including missense...

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Share to Chromosomes, Human, Pair 21

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Core Binding Factor Alpha 2 Subunit

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Identifiers

PMID: 27252013
DOI: 10.1038/ncomms11733
PMCID: PMC4895769

Genes

RUNX1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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