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Article

Effects of the Jokela type of spinal muscular atrophy-related G66V mutation on the structural ensemble characteristics of CHCHD10.

Proteins - 1 Jun 2023

Alici Hakan, Uversky Vladimir N, Kang David E, Woo Junga Alexa, Coskuner-Weber Orkid

Abstract excerpt

The G66V pathological variant of the coiled-coil-helix-coiled-coil-helix domain-containing protein 10 (CHCHD10), mitochondrial, plays a role in Jokela type spinal muscular atrophy. The wild-type and G66V mutant-type CHCHD10 proteins contain intrinsically disordered regions, and therefore, their structural ensemble studies have been experiencing difficulties using conventional tools. Here, we show our results...

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PMID: 36625206
DOI: 10.1002/prot.26463

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