Article

Aggregation-Prone Region Mapping in Olfactomedin Domain of Myocilin through Classical and Enhanced Sampling Molecular Dynamics Simulations

2025-08-02

Abstract excerpt

The aggregation of the myocilin olfactomedin (OLF) domain, generally driven by genetic mutations, is the leading cause of primary open-angle glaucoma (POAG). Developing therapeutic strategies requires a detailed understanding its initial unfolding events that expose aggregation-prone regions (APRs). However, it has been a challenge, as the slow conformational dynamics of OLF hinders classical molecular dynamics (M...

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Literature Corpus work: a2c24e92-7c71-551e-8511-a1c37df3b23f
DOI: 10.1101/2025.08.02.668245

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