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Article

Impact of disease-causing mutations on inter-domain interactions in cMyBP-C: a steered molecular dynamics study.

Journal of biomolecular structure & dynamics - 1 Jul 2017

Krishnamoorthy Navaneethakrishnan, Gajendrarao Poornima, Olivotto Iacopo, Yacoub Magdi

Abstract excerpt

The molecular interactions of the sarcomeric proteins are essential in the regulation of various cardiac functions. Mutations in the gene MYBPC3 coding for cardiac myosin-binding protein-C (cMyBP-C), a multi-domain protein, are the most common cause of hypertrophic cardiomyopathy (HCM). The N-terminal complex, C1-motif-C2 is a central region in cMyBP-C for the regulation of cardiac muscle contraction. However,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27267291
DOI: 10.1080/07391102.2016.1199329

Genes

MYBPC3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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