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Article

Neurodevelopmental disorder-associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase.

Science signaling - 3 Jan 2023

Beeman Neal, Sapre Tanmay, Ong Shao-En, Yadav Smita

Abstract excerpt

Mutations in TAOK1, which encodes a serine-threonine kinase, are associated with both autism spectrum disorder (ASD) and neurodevelopmental delay (NDD). Here, we investigated the molecular function of this evolutionarily conserved kinase and the mechanisms through which TAOK1 mutations may lead to neuropathology. We found that TAOK1 was abundant in neurons in the mammalian brain and remodeled the neuronal plasma...

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Identifiers

PMID: 36595571
DOI: 10.1126/scisignal.add3269
PMCID: PMC9970049

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