Article

Neurodevelopmental disorder associated mutations in TAOK1 reveal its function as a plasma membrane remodeling kinase

2022-07-06

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in TAOK1 , a serine-threonine kinase encoding gene are strongly associated with both autism spectrum disorder (ASD) and neurodevelopmental delay (NDD). However, molecular function of this evolutionarily conserved kinase and the mechanisms through which TAOK1 mutations lead to neuropathology are unknown. Here, we showed that TAOK1 is highly expressed in neurons within the brain, and h...

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Literature Corpus work: ab1350df-abc9-59f1-abef-462e7bf9c3c7
DOI: 10.1101/2022.07.06.499025

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