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Article

Single nucleotide polymorphisms in ADAM17, IL23R and SLCO1C1 genes protect against infliximab failure in adults with Crohn's disease.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie - 1 Mar 2023

Laserna-Mendieta E J, Salvador-Martín S, Arias A, López-Cauce B, Marín-Jiménez I, Menchén L A, Marín-Rubio L, Ontañón Rodríguez J, López-Fernández L A, Lucendo A J

Abstract excerpt

BACKGROUND: To predict primary failure of infliximab (IFX) therapy in Crohn's disease (CD) and to identify patients who maintain long-term effectiveness to IFX is currently not feasible. Some genetic variations are proposed as potential biomarkers. AIM: We assessed a set of single nucleotide polymorphisms (SNPs) in genes related to the IFX mechanism of action and the presence of HLA-DQA1 * 05 allele on the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 36621146
DOI: 10.1016/j.biopha.2023.114225

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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