Article
Infliximab dependency in children with Crohn's disease.
Alimentary pharmacology & therapeutics - 1 Apr 2009
Duricova D, Pedersen N, Lenicek M, Hradsky O, Bronsky J, Adamcova M, Elkjaer M, Andersen P S, Vitek L, Larsen K, Lukas M, Nevoral J, Wewer V, Munkholm P
Abstract excerpt
BACKGROUND: Recently, infliximab dependency has been described. AIM: To assess frequency of ID in 82 consecutive Crohn's disease children treated with infliximab 2000-2006 and to describe clinical and genetic predictors of long-term infliximab response. METHODS: A phenotype model of infliximab dependency was used to assess treatment response: 'immediate outcome' (30 days after infliximab...
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