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Article

Association between HLA DNA Variants and Long-Term Response to Anti-TNF Drugs in a Spanish Pediatric Inflammatory Bowel Disease Cohort.

International journal of molecular sciences - 16 Jan 2023

Salvador-Martín Sara, Zapata-Cobo Paula, Velasco Marta, Palomino Laura M, Clemente Susana, Segarra Oscar, Sánchez Cesar, Tolín Mar, Moreno-Álvarez Ana, Fernández-Lorenzo Ana, Pérez-Moneo Begoña, Loverdos Inés, Navas López Victor Manuel, Millán Antonio, Magallares Lorena, Torres-Peral Ricardo, García-Romero Ruth, Pujol-Muncunill Gemma, Merino-Bohorquez Vicente, Rodríguez Alejandro, Salcedo Enrique, López-Cauce Beatriz, Marín-Jiménez Ignacio, Menchén Luis, Laserna-Mendieta Emilio, Lucendo Alfredo J, Sanjurjo-Sáez María, López-Fernández Luis A

Abstract excerpt

The genetic polymorphisms rs2395185 and rs2097432 in HLA genes have been associated with the response to anti-TNF treatment in inflammatory bowel disease (IBD). The aim was to analyze the association between these variants and the long-term response to anti-TNF drugs in pediatric IBD. We performed an observational, multicenter, ambispective study in which we selected 340 IBD patients under 18 years of age...

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Source

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Identifiers

PMID: 36675312
DOI: 10.3390/ijms24021797
PMCID: PMC9861004

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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