HLA-DQA1*05 Allele Carriage and Anti-TNF Therapy Persistence in Inflammatory Bowel Disease.

doi:10.1093/ibd/izae138

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Article

HLA-DQA1*05 Allele Carriage and Anti-TNF Therapy Persistence in Inflammatory Bowel Disease.

Inflammatory bowel diseases - 10 Apr 2025

Doherty Jayne, Ryan Anthony W, Quinn Emma, Conroy Judith, Dolan Jackie, Corcoran Roisin, Hara Fintan O, Cullen Garret, Sheridan Juliette, Bailey Yvonne, Dunne Cara, Hartery Karen, McNamara Deirdre, Doherty Glen A, Kevans David

Abstract excerpt

INTRODUCTION: Carriage of the HLA-DQA1*05 allele is associated with development of antidrug antibodies (ADAs) to antitumor necrosis factor (anti-TNF) therapy in patients with Crohn's disease. However, ADA is not uniformly associated with treatment failure. We aimed to determine the impact of carriage of HLA-DQA1*05 allele on outcome of biologic therapy evaluated by drug persistence. METHODS: A multicenter,...

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Topics

Humans
HLA-DQ alpha-Chains
Female
Male
Retrospective Studies
Adult

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Alleles

Genotype

Middle Aged

Inflammatory Bowel Diseases

Tumor Necrosis Factor-alpha

Tumor Necrosis Factor Inhibitors

Treatment Failure

Follow-Up Studies

Source

Open in PubMed

Identifiers

PMID: 38937958
DOI: 10.1093/ibd/izae138

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