Disease activity, ANCA, and IL23R genotype status determine early response to infliximab in patients with ulcerative colitis.

doi:10.1038/ajg.2010.95

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Article

Disease activity, ANCA, and IL23R genotype status determine early response to infliximab in patients with ulcerative colitis.

The American journal of gastroenterology - 1 Aug 2010

Jürgens Matthias, Laubender Rüdiger P, Hartl Franziska, Weidinger Maria, Seiderer Julia, Wagner Johanna, Wetzke Martin, Beigel Florian, Pfennig Simone, Stallhofer Johannes, Schnitzler Fabian, Tillack Cornelia, Lohse Peter, Göke Burkhard, Glas Jürgen, Ochsenkühn Thomas, Brand Stephan

Abstract excerpt

OBJECTIVES: We analyzed the efficacy and safety of the antitumor necrosis factor-alpha antibody infliximab (IFX) for induction therapy in patients with moderate-to-severe ulcerative colitis (UC) in a large single-center cohort. METHODS: A total of 90 UC patients treated with IFX for 14 weeks were analyzed retrospectively. Colitis activity index (CAI) and markers of inflammation were measured during IFX induction...

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PMID: 20197757
DOI: 10.1038/ajg.2010.95

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