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Cancer Cells Upregulate Tau to Gain Resistance to DNA Damaging Agents

24 Dec 2022

Abstract excerpt

Recent reports suggested a role for microtubules in double-strand-DNA break repair. We herein investigated the role of the microtubule-associated protein Tau in radio- and chemotherapy. Noticeably, a lowered expression of Tau in breast cancer cell lines resulted in a significant decrease in mouse-xenograft breast tumor volume after doxorubicin or X-ray treatments. Furthermore, the knockdown of Tau impaired the...

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PMID: 36612113
DOI: 10.3390/cancers15010116

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