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Nutlins and Ionizing Radiation in Cancer Therapy

30 Mar 2010

Abstract excerpt

Radioresistance stands as a fundamental barrier that limits the effectiveness of radiotherapy in cancer treatment. Recent evidences suggest that radioresistance is due to tumour repopulation and involves several signalling pathways, including p53/MDM2 interaction. Ionizing radiation induces p53-dependent MDM2 gene transcription that, in turn, inhibits p53 transcriptional activity, favouring its nuclear export and...

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PMID: 20166982
DOI: 10.2174/138161210791033932

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