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Article

Drug resistance associated with loss of p53 involves extensive alterations in microtubule composition and dynamics.

British journal of cancer - 2 Jun 2003

Galmarini C M, Kamath K, Vanier-Viornery A, Hervieu V, Peiller E, Falette N, Puisieux A, Ann Jordan M, Dumontet C

Abstract excerpt

In the present study, we compared the dynamics and composition of microtubules in cell lines derived from the human breast adenocarcinoma MCF-7 containing either the wild-type p53 (wt-p53; MN1) or a dominant-negative variant of p53 gene (mut-p53; MDD2). Mut-p53 cells were significantly resistant...

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Source

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Identifiers

PMID: 12771997
DOI: 10.1038/sj.bjc.6600960
PMCID: PMC2377136

Genes

FHIT
MAP4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-12771997-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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